G/C 1000 by Progressive Labs contains a form of chondroitin sulfate and glucosamine hydrochloride that are derived naturally from crab and shrimp sources. Many manufacturers of dietary supplements use a form of glucosamine hydrochloride that includes glucosamine which is derived from shellfish sources.

Many alternative medicine practitioners believe consuming this form of glucosamine is worthwhile because it closely resembles the form of glucosamine that is produced naturally by the body. As a result. using glucosamine hydrochloride supplements that feature this form of glucosamine could be worthwhile to users who prefer to consume high-quality forms of glucosamine.